ABSTRACT
The ex vivo biosensor assay is developed to assess the health effects and toxicological mechanism of environmental pollutants with internal environment homeostasis changes by integrating the in vivo exposure evaluation, in vitro outcomes analysis, and systematic environment component screening. This toxicology testing model combines the real-world exposure of people in the field and the study of molecular mechanism exploration in lab experiments to overcome the shortcomings of a single toxicology method. It provides a new technique and perspective for toxicity testing and risk assessment in mesoscale between macroscopic population study and microscopic mechanism exploration.
Subject(s)
Humans , Biosensing Techniques , Environmental Pollutants/toxicity , Risk Assessment , Toxicity TestsABSTRACT
OBJECTIVE@#To analyze the relationship between adrenal hemorrhage and the cause of death, age and gender.@*METHODS@#Eighty-two cases of adrenal hemorrhage were statistically analyzed.@*RESULTS@#Adrenal hemorrhage occurred mostly in cases of sudden death, infection, trauma and asphyxia. Male had more chance than female to have adrenal hemorrhage. Adrenal hemorrhage caused by sudden death, trauma and poisoning was more frequently seen in young adults, whereas adrenal hemorrhage in children as well as in fetus and newborns was often caused by infection as well as sudden death and asphyxia respectively. Adrenal hemorrhage caused by sudden death and asphyxia was mainly located in medulla, while the infection usually induced hemorrhage in cortex. Adrenal hemorrhage caused by trauma showed an equal opportunity in either the cortex or medulla.@*CONCLUSION@#Our data indicate that adrenal hemorrhage might provide some clues in searching for the cause of death.